Current Position
I work as an Experimental Officer for the Manchester Centre for Integrative Systems Biology (MCISB) at the University of Manchester, with Prof. Douglas Kell (MCISB director) and Prof. Hans Westerhoff (Professor of Systems Biology at the School of CEAS). I am officially affiliated to the School of Chemical Engineering and Analytical Science (CEAS).
Research Interests
Yeast Metabolism
My main responsibility at the MCISB is the mathematical modelling of biological systems. The MCISB is pioneering the development of new technologies in Systems Biology, a new conceptual view on biological research that uses complex computational and mathematical analysis to advance traditional methods.We are developing a number a techniques for the study of the metabolism of bakers' yeast (Saccharomyces cerevisiae).
Mathematical Programming and Integer Optimisation
The object of this research is the application of mathematical programming and optimisation methodologies to problems of biological and biochemical nature. Main research areas that are examined include:
- Metabolic Pathway Analysis
- p53 Apoptotic Control Network
- Protein Folding
- Synthesis of Peptide Purification Tags for Downstream Protein Processing
Selected Publications
K. Smallbone, E. Simeonidis, D.S. Broomhead and D.B. Kell (2007) Something from nothing - Bridging the gap between constraint-based and kinetic modelling. FEBS Journal, 274 (21), 5576-5585.
E. Simeonidis, L. Dartnell, M. Hubank, S. Tsoka, I.D.L. Bogle and L.G. Papageorgiou (2005) Robustness of the p53 network and biological hackers. FEBS Letters, 579 (14), 3037-3042.
E. Simeonidis, M.E. Lienqueo, S. Tsoka, J.M. Pinto and L.G. Papageorgiou (2005) MINLP models for the synthesis of optimal peptide tags and downstream protein processing. Biotechnology Progress, 21 (3), 875-884.
E. Simeonidis, S.C.G. Rison, J.M. Thornton, I.D.L. Bogle and L.G. Papageorgiou (2003) Analysis of biochemical networks using a pathway distance metric through linear programming. Metabolic Engineering, 5 (3), 211-219.
Curriculum Vitae
A detailed online CV can be accessed here.
|
