Publications

Journal publications

  1. K Smallbone, PK Maini, RA Gatenby (2010). Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity. Biol Direct.
  2. sbmlK Smallbone, E Simeonidis, N Swainston, P Mendes (2010). Towards a genome-scale kinetic model of cellular metabolism. BMC Syst Biol 4: 6.
    doi:10.1186/1752-0509-4-6
  3. E Murabito, E Simeonidis, K Smallbone, J Swinton (2009). Capturing the essence of a metabolic network: A flux balance analysis approach. J Theor Biol 260: 445-452.
    doi:10.1016/j.jtbi.2009.06.013
  4. K Smallbone, E Simeonidis (2009). Flux balance analysis: A geometric perspective. J Theor Biol 258: 311-315.
    doi:10.1016/j.jtbi.2009.01.027
  5. M Bilalić, K Smallbone, P McLeod, F Gobet (2009). Why are (the best) women so good at chess? Participation rates and gender differences in intellectual domains. Proc R Soc B 276: 1161-1165.
    doi:10.1098/rspb.2008.1576
  6. K Smallbone, RA Gatenby, PK Maini (2008). Mathematical modelling of tumour acidity. J Theor Biol 255: 106-112.
    doi:10.1016/j.jtbi.2008.08.002
  7. sbmlMJ Herrgård, N Swainston, P Dobson, WB Dunn, KY Arga, M Arvas, N Blüthgen, S Borger, R Costenoble, M Heinemann, M Hucka, N Le Novère, P Li, W Liebermeister, ML Mo, AP Oliveira, D Petranovic, S Pettifer, E Simeonidis, K Smallbone, I Spasić, D Weichart, R Brent, DS Broomhead, HV Westerhoff, B Kırdar, M Penttilä, E Klipp, BØ Palsson, U Sauer, SG Oliver, P Mendes, J Nielsen, DB Kell (2008). A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol 26: 1155-1160.
    doi:10.1038/nbt1492
  8. CJ Kelly, K Smallbone, JM Brady (2008). Tumour glycolysis: The many faces of HIF. J Theor Biol 254: 508-513.
    doi:10.1016/j.jtbi.2008.05.025
  9. K Smallbone, E Simeonidis, DS Broomhead, DB Kell (2007). Something from nothing - Bridging the gap between constraint-based and kinetic modelling. FEBS J 274: 5576-5585.
    doi:10.1111/j.1742-4658.2007.06076.x
  10. K Smallbone, DJ Gavaghan, PK Maini, JM Brady (2007). Quiescence as a mechanism for cyclical hypoxia and acidosis. J Math Biol 55: 767-779.
    doi:10.1007/s00285-007-0105-7
  11. RA Gatenby, K Smallbone, PK Maini, F Rose, J Averill, RB Nagle, L Worrall, RJ Gillies (2007). Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 97: 646-653.
    doi:10.1038/sj.bjc.6603922
  12. K Smallbone, RA Gatenby, RJ Gillies, PK Maini, DJ Gavaghan (2007). Metabolic changes during carcinogenesis: Potential impact on invasiveness. J Theor Biol 244: 703-713.
    doi:10.1016/j.jtbi.2006.09.010
  13. K Smallbone, DJ Gavaghan, RA Gatenby, PK Maini (2005). The role of acidity in solid tumour growth and invasion. J Theor Biol 235: 476-484.
    doi:10.1016/j.jtbi.2005.02.001

Proceedings

  1. CJ Kelly, K Smallbone, T Roose, JM Brady (2007). A model to investigate the feasibility of FDG as a surrogate marker of hypoxia. ISBI 2007. 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. 540-543.
    doi:10.1109/ISBI.2007.356908

Theses

  1. K Smallbone (2006). The Role of Acidity in Tumour Development. D.Phil. thesis.
  2. K Smallbone (2002). Perfect numbers over simple algebraic number fields. M.Math. dissertation.

Preprints

  1. K Smallbone (2009). One lump or two?. Nature Precedings.
    doi:10.1038/npre.2009.4033.1
  2. AG Shaw, RJ Platt, JK Withers, N Blüthgen, K Smallbone, DA Jackson (2009). A stochastic-hybrid Model of DNA replication in mammalian cells.
  3. MJ Tindall, L Dyson, K Smallbone, PK Maini (2009). Modelling acidosis and the cell cycle in multicellular tumour spheroids.

02 Mar 10