Systems Pharmacology Group

Group's Mission

The Systems Pharmacology Group seeks to establish proper quantitative in vitro to in vivo extrapolation (IVIVE) to predict in vivo consequences upon administration of drugs to humans. Such IVIVE requires measurement of the abundance of relevant enzymes, transporters and receptors. This data will enable physiologically based computer models of molecular networks. In the first instance this group will establish robust quantitative methods to measure abundance of human drug metabolising enzymes and transporters in relevant human and animal tissues and in vitro cell lines.

Schematic

Systems Pharmacology Flow Diagram

About The Systems Pharmacology Group

The Systems Pharmacology Group has been set up to bridge the activities between the Centre for Applied Pharmacokinetic Research (CAPKR) and Manchester Centre for Integrative Systems Biology (MCISB). CAPKR is part of the School of Pharmacy and Pharmaceutical Sciences which is a premier academic centre for pharmacokinetic research in Europe.

Work at this centre extends from basic studies of transport and metabolism to development of mechanistic populations of pharmacokinetic and pharmacodynamic models. The MCISB is based in the Manchester Interdisciplinary Biocentre. Since its foundation in 2006 this group have provided a hub for systems biology research.

Current Research

Current research at the Systems Pharmacology group will implement a method for quantifying the expression of drug transporters and metabolising enzymes. The chosen method is QconCAT.